The pharmacokinetics of sulphadimethoxine were studied following
intravenous and oral (single & repeated)
administrations.
Following a single intravenous injection of 100 mg/kg body weight of sulphadimethoxine in n
ormal
chickens, serum concentration
-
time curve was best described by a two compartments open model
with elimination half life
(t
0.
5β
), volume of distribution (V
dss
) and total body clearance (CL
tot
) of
5.09
hour, 0.647
L
/kg and
0.089 L/h/kg
, respectively.
Following a single oral administration of 100 mg
sulphadimethoxine
/kg body weight in normal chickens,
the peak serum
concentration
(C
max
) was 98.07 μg/ml,
achieved at a maximum time (T
max
) of 3.01 hour. The mean systemic bioavailability
was 99.02 %. The serum concentrations of sulphadimethoxine following repeated
oral
administration of 100 mg/kg body
weight
once daily for five consec
utive days
in normal and experimentally
Salmonella Enteritidis
infected chickens
showed
a
lower significant value
recorded in experimentally
Salmonella Enteritidis
infected chickens
than in normal ones.
Sulphadimethoxine showed accumulative behavior in ser
um of
chickens.
Results of this study indicated that
sulphadimethoxine was useful for treatment of
Salmonella Enteritidis
infections in chickens.
Sulphadimethoxine was assayed
in serum,
heart, liver, spleen, kidney, fat, breast muscle, thigh muscle, skin, gizzard and brain
after 24, 48, 72, 96,120 and 144
hours
from the last daily dose of 100 mg
sulphadimethoxine
/Kg body weight for five days
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