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Prof. Mostafa Yassin Mohamed Yassin Nassar :: Publications: |
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| Title: | Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate |
| Authors: | M. Mostafa; H. M. Saber; A. A. El-Sadek; M. Y. Nassar |
| Year: | 2015 |
| Keywords: | Zirconium molybdosilicate; 99Mo/99mTc generator; characterization; performance; elution; radionuclidic purity; radiochemical purity |
| Journal: | Radiochimica Acta |
| Volume: | DOI: 10.1515/ract-2015-2488, December 2015 |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | De Gruyter |
| Local/International: | International |
| Paper Link: | |
| Full paper | Mostafa Yassin Mohamed Yassin Nassar_- Preparation and performance of 99Mo 99mTc chromatographic column generator based on zirconium molybdo.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Zirconium molybdosilicate (ZrMoSi) gel prepared using 99Mo radiotracer via peroxo route was used as a base material for 99Mo/99mTc column generator. The 99mTc elution yield and 99Mo breakthrough in the eluate were studied as a function of the pH-value of gel precipitation, gel drying temperature and Zr:Mo:Si molar ratio. Precipitation pH-value of 2, drying temperature of 100 ℃ and Zr:Mo:Si molar ratio of 0.5:0.5:1 were found to be the optimum conditions achieving 99mTc elution yield of 82% and 99Mo breakthrough of 1.0E-3%. The gel prepared with the optimum conditions was characterized by BET surface area and pore size analyzer, IR spectroscopy, thermal analysis (TGA and DTA), XRD, XRF and FESEM. Technetium-99m eluted from the optimum ZrMoSi 99Mo/99mTc generator was found to have a high radiochemical purity (98% as 99mTcO4–) and chemical purity meeting criteria of clinical grade. |
