Objective: to study the relationship between RA disease and the
IL-23R genetic variation (rs11805303) in a group of Egyptian
patients diagnosed as rheumatoid arthritis and its association with
disease activity. Patient and Methods: One hundred
participants, ranging in age from thirty to sixty years old, 56 of
whom had RA and 44 of whom were apparently healthy matched
in age and sex with patients. All participants were genotyped
using PCR/RFLP for the genetic variation (rs11805303). Data
were analyzed through Kruskal–Wallis and Mann–Whitney, chisquare (χ2), Monte Carlo tests and logistic regression. Results:
The prevalence of the rs11805303 TT genotype was 21.4% in
RA patients, which is greater than in controls (2.3 %). A much
greater association with RA was in the CT genotype (1.77 times)
and the TT genotype (5.25 times) compared to the CC genotype.
Conclusion: The study found that compared to apparently
healthy controls, RA patients are more likely to have the IL-23R
rs11805303 TT genetic variation. Additionally, greater levels of
anti-CCP were associated with the TT genotype, but higher levels
of acute phase reactants and disease activity scores are associated
with the CC genotype. |
