Abstract Objective: To evaluate angiogenin levels in both tissue and serum of patients with endometrial hyperplasia with and without atypia.
Methods: Sixty women were classified according to the histopathological findings of endometrium
into three groups. The control group consisted of 20 women with normal non-hyper plastic endometrium.
The second group included 20 women diagnosed as complex endometrial hyperplasia
without atypia. The third group included 20 women diagnosed as complex endometrial hyperplasia
with atypia. Serum and tissue angiogenin were measured by enzyme immunoassay (EIA) technique
and confirmed in tissues with Western Blotting (WB) technique.
Results: There was a statistically significant increase in serum and tissue angiogenin levels of endometrial hyperplasia groups compared to those of control group (P < 0.001). Serum and tissue
angiogenin levels were with a statistically significant higher (P< 0.001) in group III compared to
group II. The sensitivity of serum angiogenin to detect the potential possibility of endometrial
hyperplasia with atypia in endometrial hyperplasia patients was 100%, specificity 85%, positive
predictive value 86.9%, negative predictive value 100%, positive likelihood ratio 6.6%, negative
likelihood ratio 0% and accuracy 91.7%.
Conclusion: Elevated levels of serum angiogenin in endometrial hyperplasia could assist in determining
which patients are at high risk for atypical change requiring aggressive treatment.
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