Abstract
The relation of oxidative stress to the occurrence of cataract remains to
be undetermined and must be clarified. So, the aim of this work was to
study the effect of 02-free radical and some antioxidants in the pathogenesis
of senile and diabetic cataract. This work was carried on 30 patients
and 10 healthy subjects as control. They were 23 males and 17 females.
Their ages ranged from 50 to 64 years. Patients were classified into senile
cataract, diabetic without cataract and diabetic cataract groups.
Each group included 10 patients.
The results of this work showed that, in patients with senile cataract,
there were non-significant increase of fasting serum glucose (FSG) and
serum total bilirubin (serum T. bilirubin) compared with the control group.
Serum lipid peroxide (S.LP) and serum ceruloplasmin (S. Cp) were signficantly
increased (p<0.05) while plasma superoxide dismutase (SOD) and
serum uric acid were significantly decreased (p<0.05) compared with the
control group. Moreover, diabetic patients with and without cataract
showed a significant increase of FSG, S. total bilirubin, S. LP, S. Cp, and
S. uric acid (p<0.05) while plasma SOD was significantly decreased
(p<0.05) compared with the control group.
Comparative study of the diabetic cataract versus senile cataract and
diabetic without cataract, our results showed a significant increase of
FSG, S.LP, S. total bilirubin and S. Cp, while there was significant decrease
of plasma SOD in diabetic cataract compared with both senile cataract
and diabetic without cataract (p1<0.05 & p2<0.05), respectively.
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Benha M.J.
Vol. 18 No 2 May 2001
S. uric acid was significantly increased in diabetic cataract compared
with senile cataract group (p1<0.05) while it was non-significantly increased
compared with diabetic without cataract group.
Also, aqueous humor study of diabetic cataract group versus senile
cataract group showed that LP and uric acid were significantly increased
(p<0.05) while SOD was significantly decreased (p<0.05).
Correlation study revealed that, age was significantly and positively
correlated with LP, but negatively correlated with SOD both in serum and
aqueous in all patient groups. FSG was significantly and directly corrleated
with serum and aqueous LP, uric acid, S. total bilirubin, and S. Cp in
diabetics with and without cataract. Moreover, serum and aqueous LP
was significantly and inversely correlated with serum and aqueous SOD
in all patient groups, while, it was positively correlated with S. total bilirubin,
and S. Cp in diabetics with and without cataract.
We could conclude that the imbalance between generation of 02-free
radical and plasma SOD may have an etiological implication in the occurrence
of cataract. |
