| Title: | -1(SF-Evaluating diagnostic and prognostic significance of steroidogenic factor1) and gherlin in differentiation between adrenocortical adenoma, adrenocortical carcinoma and pheochromocytoma
( immunohistochemical study) |
| Authors: | Zeinab I.Elshawarby ,Eman A.Saad ,Naglaa H.Shalan |
| Year: | 2024 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Naglaa Hamed Ibrahim_paper 7.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Adrenal masses are a common finding in the adrenal gland. Steroidogenic factor 1 (SF1) is a nuclear transcription factor that regulates genes involved in gonadal and adrenal steroidogenesis. Ghrelin is a ligand of growth hormone secretagogue receptor type 1 (GHS-R1). The principal role of ghrelin is to regulate energy homeostasis and secretion of growth hormone. Aim: to differentiate adrenocortical adenoma, carcinoma and pheochromocytoma immunohistochemically using stroidogenic factor-1 (SF-1) and gherlin expression and evaluate their diagnostic and prognostic significance in relation to various clinicopathologic parameters. Material and methods: This is retrospective study carried upon 45 of different cases of adrenal gland lesions designated as: 20 cases of adrenocortical adenomas(ACA) and 10 cases of adrenocortical carcinomas(ACC) and 15 cases of pheochromocytoma . Immunohistochemical staining techniques were used to detect the role of SF-1 and gherlin in the forementioned adrenal gland lesions and evaluate their relations to different clinicopathological data and patient’s survival. |
