Different metabolic disorders including hypertension cause renal damage and increase the risk of cardiovascular events. Telmisartan, is an angiotensin II receptor blocker. Garlic in different forms has antioxidant properties. This study was designed to determine the possible protective effect of telmisartan and garlic on renal cortex of experimentally induced hypertension in rats.
Forty adult male albino rats were divided into two groups: Group I; control group (n=10), Group II (n=30); hypertension group. Group II divided into three equal subgroups. Subgroup ΙIa (hypertension only group), Subgroup IIb (hypertension with telmisartan group); rats were given telmisartan daily oral dose 10mg/kg/day for 4 weeks from the start of experiment with the induction of hypertension, and subgroup IIc (hypertension with garlic group); rats were given garlic extract i.p. daily dose 500 mg/kg/day for 4 weeks from the start of experiment with the induction of hypertension. Blood and kidney samples and measuring of systolic blood pressure were performed after 4 weeks from the start of experiment. Paraffin sections of kidneys were prepared for histological; H&E and PAS staining and immunohistochemical study for kappa B (kB).
The results revealed that the hypertension only group (subgroup IIa) showed high systolic blood pressure (mmHg), elevated blood urea level and serum creatinine with alterations in morphology of renal glomeruli and tubules and strong NF-kBexpression. Hypertension with telmisartan group (subgroup IIb) showed significant decreased (P |
