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Prof. Nahla El-eraky El-azab El-eraky :: Publications: |
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| Title: | The potential neuroprotective role of
mesenchymal stem cell-derived exosomes in
cerebellar cortex lipopolysaccharide-induced
neuroinflammation in rats: a histological and
immunohistochemical study |
| Authors: | Abeer Moustfa El-Mahalaway & Nahla El-Eraky El-Azab |
| Year: | 2020 |
| Keywords: | Cerebellar cortex; exosome; lipopolysaccharide; neuroinflammation |
| Journal: | ULTRASTRUCTURAL PATHOLOGY |
| Volume: | 44, |
| Issue: | 2 |
| Pages: | 159–173 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
Lipopolysaccharide (LPS) is an endotoxin that prompts neuroinflammation and initiates neurodegenerative disorders. Exosome is a recent therapeutic agent for many diseases such as neurological diseases. This study aimed to evaluate the potential protective role of bone marrow mesenchymal stem cell-derived exosomes (BMSC-EXs) in cerebellar cortex LPS-induced neuroinflammation in rats. Twenty-seven adult male rats were divided into three groups: Group I: control rats; Group II: LPS-treated rats; Group III: LPS/BMSC-EXs-treated rats. Cerebellar specimens were taken and processed for histological and immunohistochemical analysis. Morphometrical studies and statistical analysis were done. Groups II showed neuronal degeneration and apoptosis. The mean number of Purkinje cells was significantly (P |
