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Prof. Nancy Wadie Mikhael Abdelmasih :: Publications: |
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| Title: | Abnormalities of p53 protein expression in basal cell carcinoma and squamous cell carcinoma |
| Authors: | Ayman El Gendy* , Nancy Wadea*, Mohamed khalifa*, Nadia mokhtar**, Nadia El hefnawy*** , Asmaa El Refaie*, Hanan Sabry* and Somia Mahmoud* |
| Year: | 2002 |
| Keywords: | Not Available |
| Journal: | Journal of pan – Arab league of dermatologists, |
| Volume: | 13 |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
Mutations of p53 tumor suppressor gene are found in more than 50% of all human malignancies. The aim of this study was to investigate the expression of p53 in squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). This study was conducted on ten patients with malignant skin lesions (five cases with SCC and five cases with BCC and ten controls. P53 was identified by immunohistochemical stains using monoclonal antibodies against p53 (Do7). All cases of BCC showed positive nuclear staining of p53 (2cases showed moderate expression while 3 cases showed severe expression). Also, all cases of SCC were positive for p53 (one case showed moderate expression while four cases showed severe expression). All biopsies of controls showed negative staining for p53. There was insignificant difference between BCC & SCC cases. There was insignificant correlation between p53 expression and histopathological grading of SCC. P53 is a valuable biomarker for skin tumors and its dysfunctional expression may contribute to the development of both SCC and BCC. |
