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Dr. Nashwa Hassan Mohamed Abo-Rayah :: Publications: |
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| Title: | Prophylactic Evidence of MSCs-Derived Exosomes
in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond
Mechanistic Target of NRG-1/Erb Signaling Pathway |
| Authors: | Nesrine Ebrahim 1,2,†, Hajir A. Al Saihati 3,†, Ola Mostafa 1 , Amira Hassouna 4 , Sameh Abdulsamea 5 , Eman Abd El Aziz M. El Gebaly 6 , Nashwa Hassan Abo-Rayah 6 et al , |
| Year: | 2022 |
| Keywords: | trastuzumab; doxorubicin; stem cells; exosomes; cardiac toxicity; NRG-1; MAPK; AKT |
| Journal: | International Journal of Molecular Sciences |
| Volume: | 23 |
| Issue: | Not Available |
| Pages: | 1-36 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Nashwa Hassan Mohamed Abo-Rayah_5.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity. Mesenchymal stem cells (MSCs)-derived exosomes are nanosized vesicles that play a crucial role in cell–cell communication and have shown efficacy in the treatment of various diseases. In this study, we aim to investigate the cardioprotective effects of MSCs-derived exosomes in a DOX/Trz- mediated cardiotoxicity model, and the possible mechanisms underlying these effects are elucidated. Forty-nine male rats were randomly assigned into four groups: Group I (control); Group II (Dox/Trz); Group III (protective group); and Group IV (curative group). Cardiac hemodynamic parameters, serum markers of cardiac injury, oxidative stress indices, and cardiac histopathology were investigated. |
