Increase motility and viability of in vitro preserved sperms is crucial for the success of assissted fertilization especially in.cases of, semen quality as in varicocele patients. In those patients, sperm viability. and motility" are decreased due to testicular ischemia, impaired venous draiinage and production of toxic metabolites.In this.work, the effect of two drugs with profound
anti-ischemic. properties namely adenosine,and RiSZSI bdr. -,
tgs_ted,on sperm motility an{ viability o_f varie ocele patients . Tt + ,., . ; . ,
tested drugs share a common property of increasirrg tissue /
adenosing-.Moreover the effect of tested drugs on motility of
guinea pig vas deferens and ,ATPase activity of rat testicular
homogenates were investigatd. Regarding sperrn motility and
viability, R7 5Z3L but not adenosine improved the above
mentioned sperm propertfuis .It also decreased ATPase activity of
rat testicular homogenates On the otherhand, both drugs
potentiated adrenaline induced contraction of vas deferens ofguinea
pig. The latter effect was inhibited by 8-SPT a broad
spectruum adenosine receptor blocker. This may irnply the
presence of smooth muscle stimulatory adenosine receptors of :
AZ type in vas deferens of guinea pig. The therapeutic relivance
and mechanisms of action of tested drugs in varicocele induced
infertility- were explained. |
