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Prof. Nasr N. Makar :: Publications: |
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| Title: | A comparative study between some pharmacological effects of rilmenidine versus captopril on experimentally-induced diabetic
nephropathy in rats. |
| Authors: | Nasr N. Makar, Ahmed S. Mohamed, Mahmoud M. Al_Fouly, Samia M. Al-Sheety, Nashwa H. Abu_Ria. |
| Year: | 2010 |
| Keywords: | Not Available |
| Journal: | THE ANNUAAL MEDICAL CONGRESS BENHA FACALTY OF MEDICINE |
| Volume: | Not Available |
| Issue: | 5 |
| Pages: | 21 |
| Publisher: | THE ANNUAAL MEDICAL CONGRESS BENHA FACALTY OF MEDICINE |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
AIM: to assess the effects of both rilmenidine and captopril on fasting blood glucose (FBG) level, urine albumin. and kidney histopattrotogy in streptozotocin (STZ)-induced diabetic nephropathy rats. METHOD: 24 spraruge Dawley male rats weighing berween 150-250g were administered single dose STZ (l00mg/kg) intraperionially and examined after 4 weeks for FBG, urine albumin and.kidney histopathology. the rats were divided into 4 groups: normal contror, diabetic nephropathy, rilmenldine-treated and captopril-treated groups. Rats received rilmenidine (lmg/kg/day) intraperitonially for 4 weeks and captopril (100mg/kg/day) orally for 4 weeks. RESULTS: rimenlidine significantly decreased FBG and significantly reduced urine albuimin. captopril significantly (p |
