Background: Triclosan (TCS) is a widely used antiseptic compound that has been added to personal care products. Triclosan is absorbed through mucous membranes of the oral cavity and gastrointestinal tract after oral exposure and through the skin after dermal exposure. It is suspected to be a potential reproductive toxicant. Aim : assessment of the chronic toxicity of triclosan on testes and ovaries of normal adult albino rats through measuring the level of hormones as testosterone,estrogen ,FSH and LH and assessment of histopathological and ultrastructural changes in testes and ovaries . Methods : A total of 80 normal adult albino rats (40males and 40 females) were used ,the animals were divided into 8 equal groups (10 rats per each group) as follows:Group-I (Male Control Group),Group-II (Female Control Group),Group-III (Vehicle-Treated, Acacia Gum Treated Male Group),Group-IV (Vehicle-Treated, Acacia Gum Treated Female Group),Group-V (Triclosan orally Treated Male Group),Group-VI (Triclosan orally Treated Female Group), In Group-VII (Triclosan dermally exposed male Group , group VIII( Triclosan dermally exposed Female Group) ,the groups received doses of triclosan(For oral groups:435 mg/kg body weight, For skin exposed groups: 600 mg/kg body weight) for twelve weeks . Results : Decreased levels of measured hormones , Low sperms count and motility, histopathological and ultrastructural changes in testes and ovaries in oral and dermal exposed groups. Conclusion : Triclosan caused low levels of sex hormones as testosteron,estrogen, FSH and LH, It affected sperms count and motility and It caused histopathological and ultrastructural changes in testes and ovaries. |
