Background: Chronic renal failure (CRF) is defined as the presence of kidney damage, which quantified by measured glomerular filtration rate (GFR). CRF has emerged as a global public health burden for its increasing number of patients, high risk of progression to end-stage renal disease (ESRD), and poor prognosis of morbidity and mortality Multiple shared risk factors for chronic kidney disease (CKD) and hearing loss include age, diabetes, hypertension, and medications that are both ototoxic and nephrotoxic. Moreover, in patients with established CKD, multiple risk factors have been hypothesized to cause hearing loss including the use of ototoxic medications, hypertension, and diabetes, particularly in association with hypertension, electrolyte disturbances, and hemodialysis itself. Both organs are involved in body fluid homeostasis, The inner ear and the kidney share a series of basic processes for water and ion regulation as well as some specific cellular water channels known as aquaporins, which are known to have a crucial role in the functional activity of both organs. both organs have epithelium containing a sodium– potassium energy-requiring processes linked to the strict necessity of maintaining the balance of ions and a stable pH. Aim of the Work: to determine the presence, type, and severity of hearing loss (HL) in patients with chronic kidney disease on regular hemodialysis and on conservative management and to evaluate the relationship of reported HL with the duration of hemodialysis of children with chronic renal failure on regular hemodialysis. Patients and Methods: This study will be a case control study including 30 patients with chronic renal failure on regular hemodialysis in the Nephrology Unit, Pediatric Department, Benha University Hospitals and 20 Patients with chronic kidney disease on conservative management and 30 healthy children as a control group. All children are subjected to standard and extended pure-tone audiometry and tympanometry. Results: Our study found that 43.3 per cent of CKD patients on haemodialysis had sensorineural hearing loss and 40 % of CKD patients on conservative management . SNHL was mainly at high frequencies (47.6%) and of mild and moderate severity. Our study showed that there was statistically significant relation found between SNHL and hypertension in CKD patients but there was no significant relation found with the duration of hemodialysis or hematological parameters and biochemical parameter except serum sodium level. |
