Introduction: Numerous treatments have been attempted to treat keloids and hypertrophic scars (HTS) with unsatisfactory results using either single or combination modalities. Intralesional Five fluorouracil (5-FU) has not been much investigated in treatment of HTS. Intralesional bleomycin has been documented for treatment of keloids and HTS with promising results. Objective: the aim of this work was to evaluate the efficacy of intralesional injection of 5-FU alone or combined with Triamcinolone acetonide versus bleomycin in treatment of keloids. Patients and methods: sixty patients with keloids were included in this study, they were divided into the following groups: group (IA): included 15 patients injected intralesionally with 5-FU; group (IB): included 15 patients injected intralesionally with a mixture of Triamcinolone acetonide (TAC) + 5-FU; Group (II): included 30 patients injected intralesionally with bleomycin. The patients underwent follow up by photographing and Vancouver scar scale system at 4, 8, 12 weeks during treatment period and after stopping treatment for 6 months. Results: group IA: the mean Vancouver scar scale before and after treatment was 9.67 ± 1.35 and 4.47 ± 1.3 respectively, with mean total improvement of 54%. In group IB: the mean Vancouver scar scale before and after treatment was 9.67 ± 1.63 and 4.46±1.55 respectively with mean total improvement of 55%. In group II: the mean Vancouver scar scale before and after treatment was 9.32 ± 1.46 and 2.7 ± 0.95 respectively with mean total improvement of 73%. Comparison between The mean values of Vancouver scar scale in group II and group I after treatment was statistically significant (P |
