Aim of Study: This work aims to determine serum and synovial levels of the granulocyte colony stimulating factor (G-CSF) in order to evaluate their utility as biomarkers of disease activity and severity in rheumatoid arthritis (RA) patients. Methods: Thirty patients with established RA and a control group of 20 apparently healthy individuals matched for age and sex to our patients were included and thoroughly examined. Disease activity was assessed using the modified disease activity score of 28 joint count (DAS28) while, disease severity was evaluated using the clinical spread severity Index (SSI). Plain radiography was done for all affected joints with evaluation according to Laresn scores Serum and synovial levels of (G-CSF) were measured by the ELISA technique.Conclusion: . Our results reveal a critical role for G-CSF in driving joint inflammation and highlight G-CSF as a potential therapeutic target in rheumatoid arthritis. |
