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Prof. Nehad Ahmed Foad :: Publications: |
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| Title: | Serum and synovial survivin in rheumatoid arthritis: Relation to
disease activity and severity |
| Authors: | Eman Barakaa, Mounir Serag El Dina, Ahmed El Shambkya, Nehad A. Fouadb, Mona Abdullah Abdelkader |
| Year: | 2019 |
| Keywords: | Not Available |
| Journal: | Egyptian Rheumatology & Rehabilitation |
| Volume: | 46:221–228 |
| Issue: | Not Available |
| Pages: | 46:221–228 |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Nehad Ahmed Foad_survivin.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Rheumatoid arthritis (RA) is a progressive debilitating autoimmune disease, affecting 1% of the world population, leading to cartilage and bone destruction caused by insufficient apoptosis in the inflamed RA synovium. Survivin is a protooncogene biomarker known for its anti-apoptotic and cell cycle-regulating properties. Overexpression of survivin in non-cancerous processes has been linked to inflammation, presumably contributing to the decreased apoptosis in the T cells of the cerebrospinal fluid in multiple sclerosis, in skin lesions of patients with psoriasis and in synovial tissue of patients with RA. |
