Background: High-mobility group box 1 (HMGB1) has important
role in a variety of diseases, including neonatal sepsis (NS). The aim of
this study is to evaluate the clinical importance of HMGB1 genetic
expression in NS demonstrating its diagnostic value and detecting the
effect of its genetic expression on the disease outcome. Patients and
Method: This study was carried out on 100 neonates; 28 neonates with
clinical sepsis and had positive blood cultures (confirmed), 22
neonates with clinical sepsis but had negative blood cultures
(suspected) and 50 healthy non-infected newborns age and sex
matched as controls.Results: Expression of HMGB1 in newborns with
confirmed NS and those with suspected NS were higher than healthy
controls. Also, it was higher in newborns with confirmed NS than
those with suspected NS. The sensitivity and specificity of the
diagnostic value of HGMB1 were higher than that of C-reactive
protein (CRP) and hematological score (H score). Assessment of the
HMGB1 for prognosis of the disease was evaluated by univariate
analysis (p= |
