The present study was designed to compare the benificial prophylactic effects of nebivolol and lisinoprilon the progression of diabetic nephropathy in a rat model of streptozotocin induced diabetes. Animals were classified intoNormal Control group (received no medication), Utreated diabetic group induced by administrated of single I.P injection 65mg/kg of streptozotocin "STZ", Nebivolol treated diabetic group (2mg/kg p.o) for 7 weeks,Lisinopril treated diabetic group (1mg/kg p.o) for 7 weeks. The obtained results in the current work revealed that induction of diabetes by streptozotocin resulted in significant increase of fasting blood glucose level (FBG), serum urea level, serum creatinine level, 24hrs urinary albumin excretion (UAE) and significantly decrease renal blood flow (RBF), shows significant changes in histological findings in the kidney as compared to control group. While nebivolol treated group resulted in decrease FBG, serum urea, serum creatinine levels, decrease UAE and significantly increased RBF. It shows improvement in the histological findings as compared to untreated streptozotocin (STZ) induced diabetic nephropathy. Lisinopril treated group resulted in no changes in FBG level, significantly decreased serum urea level, serum creatinine level, decreased 24hrs UAE level and increased RBF. It also shows improvement in the histological findings as compared to untreated streptozotocin (STZ) induced diabetic nephropathy. Conclusively: Nebivolol may replace ACE inhibitor as the first choice drug in diabetics for prevention of end organ damage. Lisinopril have the superiority in improvement the parameters of kidney function but nebivolol show marked improvement of the pathological changes occured in untreated diabetic nephropathy group and significantly increase renal blood flow. |
