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Dr. Omnia Alsaid Abdallah :: Publications: |
|
| Title: | Genetic Variations in the Growth Arrest–Specific 6
(GAS6) Protein Gene in Patients with Acute Coronary
Syndrome |
| Authors: | Mohamed Mohamed Elshafey MD , Jehan Hassan Sabry MD , Omnia El Saeed Abdlla MD and Rania Fouad Abdel Ghany M.B.B.Ch . |
| Year: | 2015 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Omnia Alsaid Abdallah_paper.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Growth arrest–specific gene 6 (GAS6) encodes a vitamin K– dependent protein that regulates inflammation, angiogenesis, and atherosclerotic plaque formation. The level of GAS6 expression is associated with plaque stability and stroke. The role of GAS6 in cardiovascular disease, particularly in acute coronary syndrome (ACS) was explored .The study investigated the role of the single nucleotide polymorphism (c.834+7G>A) of GAS6 in ACS. The genotype frequencies for GG, AG, and AA, respectively, in patients with ACS were 57.1% (16/28), 28.6% (8/28), and 14.3% (4/28) and were 20% (4/20), 40% (8/20), 40% (8/20) in the control group. The AA genotype and A allele were less frequent in patients with ACS than in control subjects (P |
