Objectives : to determine the frequency of acute kidney injury (AKI) among paients admitted to surgical intensive care unit (ICU) for variant indications and to determine the predictability of at admission AKL biomarkers levels for the possibility of AKL development . patient &Method : the study included 168 patient with mean age 3+ - 6.7 years ; 97 postoperative patients, 55 trauma patients and 16 patients had other causes . patients data were collecated and disease severity was evaluated using the acute physiology and chronic health Evaluation (APACHE11) and the simplified therapeutic Intervention Scoring System (TISS-28).
Development of AKL Within the first 48 hours after ICU admission was defined according to the Acute kidney Injury Network (AKIN ) criteria using serum creatinine (sCr).Blood samples were obtained for ELISA estimation of at admission (sCr) and serum Cystain C (CysC) and plasma Neutrophical gelainase – associated lipocalin (NGAL) levels . Another blood sample was obtained at 48 hours of ICU admission for colorimetric estimation of sCr and then paients categoriziation results:Estimated sCr at 48-hr after admission defiend 62 patients developed AKL stage -1(23.3%) and 23 patients AKL stage -2 (13.7%) . at admission plasma NGAL levels were significantly higher in patient compared to controls , however , AKL-free patients showed non - developed AKL had significantly higher in patient compared to controls. Patients developed AKL –free patients with significantly higher levels in patients developed AKL-2 compared to those developed AKL-1 . At admission serum CysC levels were significantly higher in patients |
