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Prof. OSAMA ABDELWAHAB ABDALLA MAHMOUD :: Publications:

Title:
A comparative study between full-dose and half-dose intravesical immune bacille Calmette–Gue´rin injection in the management of superficial bladder cancer
Authors: Wael Kandeel, Ashraf Abdelal, Basheer N. Elmohamady *, Ahmed Sebaey, Waleed Elshaaer, Ehab Elbarky, Osama Abdelwahab
Year: 2019
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Osama abdelwahab abdallah mahmoud_BCG.pdf
Supplementary materials Not Available
Abstract:

t Objectives: To determine whether a half-dose of bacille Calmette–Gue´rin (BCG) can reduce toxicity without affecting its efficacy in the management of nonmuscle-invasive bladder cancer. Patients and methods: From January 2012 to January 2014, 80 patients with superficial bladder cancer and in the intermediate-risk group were simply randomised to receive two different doses of BCG, i.e., a full dose of 90 mg (group A) or a half-dose of 45 mg (group B). There were no significant differences in clinical and pathological characteristics between the groups. At completion of the study, 40 patients could be evaluated in each group. Results: All patients were evaluated for a follow-up of 12 months after treatment. There was no significant difference in recurrence rate (15 patients, 38%, in group A and 16, 40%, in group B) in the two groups, and no difference in progression rate of the disease, at eight patients (20%) in each group. There were significant differencesbetween groups A and B in toxicity (grade 1 adverse events, 70% vs. 60%; grade 2, 18% vs. 7.5%, respectively). Grade 3 adverse events were only reported in group A (2.5%). Conclusion: The half dose of intravesical BCG instillation can reduce the toxicity and side-effects that are associated with the treatment of superficial bladder cancer, without affecting the efficacy of therapy.

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