Hypothesis / aims of study
Voiding Dysfunction is commonly associated with Benign Prostatic Hyperplasia (BPH).Some men with (BPH) find nocturia to
be their most troublesome symptom, because it interferes with sleep.
Alfa blockers alone sometimes is not sufficient to relief nocturia ,although it improves (BPH) symptomes . The aim of this study
is to address the efficacy and safety of low dose Desmopressine with Alfa Blocker in treatment of Nocturia due to BPH.
Study design, materials and methods
This study was conducted on 170 patients with symptoms of BPH and nocturia. Patients were divided randomly into 2
groups:Group A( 95 patients) received Xatrale xl 10 mg daily plus Minirine Melt 60 mcg at bed time and Group B( 75) patients
received xatrale xl 10 mg daily alone.All patients were evaluated at 1st visit,and monhly for three months by history(including
IPSS symtome score,Frequency volue chart FVC ) physical examination,urine analysis, serum sodium ,pelviabdominal
ultrasonography,and flowmetry.Exclusion criteria are cardiac patients and patients with hyponatremia or age above60 years.
Results
170 patients were included with no significant age difference 43+ G A and 45+5 G B. Both groups had significant improvement
in IPSS score from the base line till 1,2 and 3 months follow up ( P |
