Background: CD30 (cluster of differentiation) is a membrane antigen belonging to the so called activation
antigen that are induced in lymphocytic cells following their activation.
Objective: Assessment of CD30+ cells status in benign inflammatory infiltrate of some dermatological diseases such as psoriasis, lichen planus and scabies in Nile Delta, Egypt.
Patients & Methods: This study conducted on 30 patients with three benign inflammatory skin diseases (psoriasis, lichen planus and scabies) and 10 normal volunteers as controls. Skin biopsies were taken from all patients and normal controls under local anasethia. All specimens were stained by hematoxylin and eosin for routine histopathological diagnosis. Each disease was classified into early and late well developed stage according to duration and pathological findings. Immunodetection of CD30+ cells were performed. In each biopsy specimen, the distribution and the number of CD30+ cells were evaluated as follows: isolated weak positive cells (+), small non-cohesive aggregates (3-5cells) of positive cells (++) and large aggregates (> 5 cells) of strong positive cells (+++).
Results: Histopathologically, the skin lesions of the three diseases showed the classical pathological findings. It was found that two out of ten normal human specimens gave a weak positive (+) staining for CD30+ cells. All late cases of psoriasis (6 cases), lichen planus (4 cases), and scabies (7 cases) stained positive (++) or strong positive (+++)] for CD30.
Conclusion: CD30 antigen expression occurs in benign inflammatory infiltrate of some benign skin conditions such as psoriasis, lichen planus and scabies.
Key words: CD30 –Psoriasis – Lichen planus- Scabies
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