Introduction: One of the widely used gastro protective agents
are H2 receptor antagonists (H2RAs). But these drugs may
induce several adverse effects. Recent studies have shown that
mesenchymal stem cells (MSCs) play an important role in the
healing of gut injuries. Aim of the work: To evaluate the role of
bone marrow- mesenchymal stem cells (BM- MSCs) in the
treatment of gastric ulcer, and to compare their efficacy with
H2RAs therapy. Methods: 10 out of the 50 adult albino rats
used in this study served as donors for stem cells and the other
40 rats were divided into four groups: Group I (control group).
Group II (Gastric ulcer group), rats received 200mg /kg
ibuprofen suspended in CMC-Na 1% given orally by gastric
tube. Group III (Nizatidine treated group), rats with gastric ulcer
were treated with 31.25 mg/kg nizatidine, given orally by gastric
tube. Group IV (BM-MSCs treated group), rats with gastric
ulcer were injected with BMMSCs in the rat tail vein. Results:
MSCs-treated group revealed improvement of histological
structure and restoration of the normal architecture of the gastric
mucosa. Nizatidine-treated group demonstrated nearly similar results to that of MSCs treated
group. A significant decrease of tumor necrosis factor α (TNF-α) expression was observed in
MSCs-treated group as well as nizatidine-treated group when compared to ulcer group
(P |
