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Dr. Basant M. Elnady Esawy :: Publications:

Serum Soluble CD 163 and its relation to various disease parameter in patients with systemic sclerosis
Authors: W Hassan; Basant M Elnady;Eman A. Baraka; Tahany M. Gouda; Nehad A. Fouad
Year: 2016
Keywords: Keywords: Systemic sclerosis; soluble CD 163; Macrophages; Modified Rodnan severity score
Journal: european journal of rheumatology
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Basant M. Elnady Esawy_n manuscript.docx
Supplementary materials Not Available

Objective: Cluster of differentiation 163 (CD163) is a receptor that binds haptoglobin-hemoglobin complexes and is expressed mainly on macrophages and monocytes. As a result of shedding, the extracellular portion of CD163 circulates in blood as a soluble CD163 (sCD163). This study aimed to measure sCD163 serum levels in systemic sclerosis (SSc) patients and to assess its relation with the clinical, laboratory and radiological features of the disease. Material and Methods: We measured sCD163 in the serum from 24 SSc patients and in the serum from 30 healthy controls. The patients were subjected to full history taking and thorough clinical rheumatological and dermatological examinations. In SSc, the skin thickness score was scored according to the modified Rodnan skin score (MRSS) method and pulmonary involvement was assessed in all patients by high resolution computerized tomography (HRCT) and pulmonary function tests (PFTs). Results: The mean sCD163 serum levels in the patients with diffuse and limited SSc was (61.64 ± 19.57 and 60.8 ± 21.43 ng/ml respectively) showed a highly statistically significant increase as compared to the mean serum levels in the control (36.97±16.37 ng/ml)(p

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