Background: Organophosphate (OP) toxicity is common in developing countries. OP toxicity classically presents with symptoms of cholinergic excess. Other organ systems affection can rarely occur but when it does, it worsens a patient's prognosis. Purpose and Objectives: We aimed to study: socio-demographic pattern and acute hepatic, renal, and cardiac toxicity of OP of patients in Benha poisoning control center (Bpcc) Patients and methods: Prospective study of acute OP intoxicated patients in Bpcc, Qalyubia, Egypt, during the period from 1st May 2015 until 30th April 2016. All patients were subjected to full history taking, complete physical examination including: level of consciousness by Glasgow Coma Scale (GCS), regular monitoring of vital signs, Severity of Poisoning (PSS) and cholinergic toxidrome, investigations: pseudocholinesterase activity( PChE level), arterial blood gases analysis, biochemical profile (serum sodium (Na), potassium (k) levels, kidney function tests, liver enzymes, and random blood sugar) and electrocardiographical (ECG) monitoring, management of cases, outcomes of OP poisoned patients after treatment and duration of hospital stay. Results: 135 (7.7%) out of 1754 were acute OP intoxicated patients presented to Bpcc. The age ranged between 0 and 70 years. The age group 10>20 years, the female patients, cases from rural areas, unmarried patients, students, indoor, oral ingestion, summer, suicidal attempt manner showed higher prevalence of poisoning. The outcome of the cases had full recovery were (121; 90%). Cholinergic toxidrome: The commonest presentations were nausea, vomiting and abdominal pain (95; 70.4%) followed by miosis in (81; 60%). Most cases were PSS=1 (mild) (68; 50.3%). Fully awake patients (GCS=15) were (64; 47.4%). A positive correlation between PSS and delay in hospital arrival was significant (P |
