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| Title: | ESTIMATION OF POSTMORTEM INTERVAL USING VARIOUS MARKERS IN THE LIVER OF ADULT ALBINO RATS (TARGETING PTEN/FASL SIGNALING PATHWAY) |
| Authors: | Rabab Fawzy Hindawy1, Eman Mohamed Faruk2, Samia M Manawy3, Basma A. Ibrahim4, Doaa Elsayed Abdelrazzak5, and Nahla Mohammed Ibrahim5 |
| Year: | 2024 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | rabab.hindawy_6.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Evaluation of period since mortality is one of the difficulties in forensic science. Autolysis triggers decomposition, which induces destructive cellular changes causing cell death. Aim: This work aimed to study mRNA expression depending on the process of cell death signaling, to evaluate alterations in antioxidant/oxidant variables and immunohistochemical postmortem changes in rats' livers. Methodology: Thirty-five rats have been classified into 5 groups. The liver was extracted at (0, 3, 6, 12, 24) hours postmortem, to measure the mRNA expression of FasL, PTEN, caspase-3, Bax, and Bcl2 by quantitative PCR in addition to MDA, CAT, GPx, and immunohistochemical postmortem changes. |
