Background: Neurotoxicity of tramadol which is used as a potent analgesic considers a significant
public health concern. Resveratrol has antioxidants, anti- inflammatory and anti-apoptotic
characters, therefore elicits cerebral oxidative disturbances, it offers neural protection. Aim: this
experimental study aimed at assessing the tramadol’s toxic impacts on brain of adult albino rat
behaviorally, biochemically, histopathological, and immuno-histochemical, and to explore the
potential ameliorative effect of resveratrol. Materials & Methods: fifty rats weighing 180-200
gm were used and parted into four groups: two Control groups [Negative, and Solvent], resveratrol
(20mg/kg B.W./day) group, tramadol group (50mg/kg/day), tramadol+ resveratrol group. for 28
days. Results: Resveratrol relieved the cognitive deficit and oxidative stress (CAT, & GPx
concentrations raised significantly (P |
