Expanded use of Chloroquine and hydroxychloroquine drugs for non-malarial disease
entities has resulted in prolonged duration of therapy and higher daily dosages leading to
cumulative doses greater than those used in antimalarial therapy. The aim of the study is to
evaluate and compare the toxic effects of chloroquine and hydroxychloroquine on different
organs of albino rats. The study was conducted on 60 normal albino rats divided into 3
groups, the 1st group is the control group that received only distilled water, the 2nd and the 3rd
group were given a single daily oral doses equivalent to 1/10th of LD50 chloroquine and
hydroxychloroquine respectively. Assessment of liver and kidney functions, and
histopathological changes in liver, kidney, and heart in different groups was done. The
chloroquine treated group showed significant elevation of serum glutamic pyruvic
transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), alkaline
phosphatase (ALP), total bilirubin (TB), serum creatinine-urea (Cr-U), Creatine Kinase-MB,
C-reactive protein and Malonic dialdehyde levels as compared to control and
hydroxychloroquine treated group. The histopathological evaluation showed marked hydropic
degeneragtion, vascular congestion, interstitial hemorrhage, and necrosis in the liver, kidney
and heart of chloroquine treated group, while hydroxychloroquine treated group showed mild
congestion and slight cellular degeneration. Thus, hydroxychloroquine is less toxic and
physicians should prescribe it better than chloroquine. Chloroquine if prescribed for
therapeutic uses should be taken for short periods.
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