Background: Obesity is a multifacterial condition that involve complex interactions of metabolic, physiologic, social and behavioral factors. Obese individual has an increased incidence of non alcoholic fatty liver disease (NAFLD) which is one of the most common causes of chronic liver disease. The complications of NAFLD remain undescribed. Aim of the work: was to determine the progression of complications of NAFLD. Material and Methods: 20 liver biopsies from female patients’ were evaluated and categorized, according to the NAS(Non Alcoholic ActivityScore) system. Biopsies were processed for histopathological and immunohistochemical study beside liver function tests. Results:Liver biopsies from obese person showed single or multiple fat droplets inside the cytoplasm of the most of liver cell, ballooning of hepatocytes with positive immunohistochemical reaction for Mollary bodies occurred. Moreover inflammatory cells were detected in hepatic lobules together with hepatic cell necrosis. These changes were associated with pericellular ad peiportal fibrosis. There were significant increases in liver functions (P< 0.05). Conclusions:It is likely that regular assessment of liver functions and histopathological changes in obese will continue to play an important role in the diagnosis and management of people with NAFLD. Recommendations:Further studies are still required to determine the role of liver biopsy and liver function tests in monitoring therapeutic responses. The grading and staging NAFLD also requires further evaluation. |
