Cancer prostate is the fifth most common male cancer in Egypt
after urinary cancers, liver cancer, Non-Hodgkin lymphoma and lung
cancer.
S100A4 is a marker that has been proposed to be implicated in
tumorogensis, invasion and metastasis of many malignant tumors.
The aim of this study was to evaluate the expression of S100A4 in
benign prostatic hyperplasia and prostate adenocarcinoma cases and to
compare these results with the clinicopathological data trying to assess
the role of S100A4 in prostate adenocarcinoma. Statistical analysis was
made for all grades.
This retrospective study was carried on 42 cases of prostatic
lesions. Eight cases of benign prostatic hyperplasia (BPH) were taken as
control and 34 cases of prostatic adenocarcinoma, 13 cases of them were
grade I, 11 cases were grade II and 10 cases were grade III.
Histopathological examination of the cases revealed significant
positive statistical correlations between Gleason grade of prostate cancer
and capsular invasion, lymph node metastasis, associated high grade PIN,
perineural invasion and preoperative PSA level. However, no significant
statistical correlations were found between Gleason grade and the stage or
5 years survival.
S100A4 immunostaining was performed for each case and was
correlated with clinicopathological parameters. S100A4 was detected as
cytoplasmic and occasionally nuclear brown granules and was scored as 0
or 1 (-) and 2 or 3 (+) , 4 or 5 (++) , 6 or 7 (+++) or 8 or 9 (++++).
There was a significant statistical correlation between the Gleason
score of prostate carcinoma and the score of S100A4 expression (P value
< 0.05). This means that S100A4 might be involved in prostate
adenocarcinoma progression and carcinogenesis.
There was a significant statistical correlation between the score of
S100A4 expression and the presence of capsular invasion and/or lymph
node metastasis (p value 0.05) which needs further work to find out if S100A4 protein has a role
in prostatic adenocarcinoma aggressiveness.
There was insignificant statistical correlation between the presence of
perineural invasion and the score of S100A4 expression (p value >0.05).
There was insignificant statistical correlation between the score of
S100A4 expression and the presence of associated high grade PIN in
malignant cases (p value >0.05).
There was insignificant statistical correlation between 5 years survival
and the score of S100A4 expression (p value >0.05).
Further studies may be needed to detect prognostic value of S100A4
in prostate adenocarcinoma. |
