Background The surgical treatment of obesity improves metabolic abnormalities in patients with type 2 diabetes.The aim of this study was to evaluate the immediate and late effect of bariatric surgery on GLP-1 , metabolic parameters and insulin resistance in patients with T2DM.
Methods fifty patients with T2DM ,obese at levels II and III(BMI more than or equal to 35) were evaluated for BMI , WC , BP , PPGLP-1 , fasting plasma glucose , fasting insulin and HOMA-IR before , 1w and 3m after intragastric ballon insertion , RYGBP and SG and evauated for Lipid profile , HbA1C , ALT and AST before and 3m after .Results: the study demonstrated significant increase of PPGLP-1 after RYGBP and SG with better results in RYGBP .No significant change noted after IGB insertion. The metabolic parameters significantly improved in the 3 groups with best results in RYGBP group then SG group followed by IGB group.Conclusion: Our data suggest that the RYGB and SG surgeries,beyond weight loss, induces early beneficial changes in PPGLP-1which favor glycemic control in type 2 diabetes. |
