Doxorubicin (DOX) is highly effective antineoplastic agent, but it has side effects including cardiotoxicity.
Moringa oleifera and vitamin E are potent antioxidants that prevent
cardiotoxicity. Objective: evaluate the possible protective role of
moringa oleifera and vitamin E on doxorubicin-induced
cardiotoxicity. Materials and Methods: Sixty-five adult male
albino rats were randomly divided into five groups. Group I
(control group). Group II (affected group): rats were injected
intraperitoneally with a cumulative dose of 15 mg/ kg of DOX for
three weeks. Group III (moringa group): given in a dose of (500
mg/ kg/ day) by gastric tube orally for four weeks. Group IV
(vitamin E group): given in a dose of (100 mg/ kg/ day) by gastric
tube orally for four weeks. Group V (moringa and vitamin E).
Heart specimens were taken and prepared for histological,
immunohistochemical and EM examination. Results: Group II
showed disorganized, widely separated muscle fibers, cytoplasmic vacuolation, pyknosis of
many cardiomyocyte nuclei, the mitochondria appeared distorted, extravasation of RBCs and
inflammatory infiltrations. There was significant increase (P |
