| Title: | Protective impact of intermittent fasting versus Tauroursodeoxycholic acid (TUDCA) on Amoxicillin-Clavulanate-induced hepatotoxicity via autophagy modulation and down-regulation of endoplasmic stress in albino rats. Histological and Immunohistochemical study |
| Authors: | Marwa A. Saad, Nahla E. El-Azab, Heba E. Bayoumi and Rania E. El-Desoky |
| Year: | 2026 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
Background: Drug-induced liver injury (DILI) may progress to liver failure. Tauroursodeoxycholic acid (TUDCA) has shown hepatoprotective potential, while intermittent fasting (IF) has also been reported to exert beneficial effects on liver injury. Objective: To investigate and compare the protective effects of intermittent fasting and TUDCA against amoxicillin-clavulanate (Amox-C)-induced liver injury in adult male albino rats. Materials and Methods: Thirty-two adult male albino rats were randomly divided into four groups: Group I (control), Group II (Amox-C), Group III (IF + Amox-C), and Group IV (TUDCA + Amox-C). Group II received oral Amox-C (60 mg/kg/day) by gastric gavage for 10 consecutive days. Group III received Amox-C at the same dose while undergoing intermittent fasting. Group IV received TUDCA by intraperitoneal injection 30 minutes before oral administration of Amox-C. Results: Group II exhibited marked liver injury characterized by hepatocellular degeneration, hepatitis, dilated blood sinusoids, and congested and dilated central veins. In contrast, Groups III and IV showed significant improvement in the hepatic histological architecture compared with the Amox-C group. Conclusion: Both TUDCA and intermittent fasting attenuated Amox-C-induced liver injury. However, intermittent fasting produced greater improvement in hepatic histological architecture and reduced P62 immunoexpression to a greater extent. |
