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Dr. Rasha Orban Mahmoud Abdulkarim :: Publications:

A Novel Method for Survival Prediction of Hepatocellular Carcinoma Using Feature-Selection Techniques
Authors: Mona A. S. Ali, Rasha Orban, Rajalaxmi Rajammal Ramasamy, Suresh Muthusamy, Saanthoshkumar Subramani, Kavithra Sekar, Fathimathul Rajeena, Ibrahim Abd Elatif Gomaa, Laith Abulaigh and Diaa Salam Abd Elminaam
Year: 2022
Keywords: HCC; imbalance data; LASSO regression; ridge regression; random forest; recursive feature elimination
Journal: Applied Sciences
Volume: 12
Issue: 13
Pages: 6427
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Not Available
Supplementary materials Not Available

The World Health Organization (WHO) predicted that 10 million people would have died of cancer by 2020. According to recent studies, liver cancer is the most prevalent cancer worldwide. Hepatocellular carcinoma (HCC) is the leading cause of early-stage liver cancer. However, HCC occurs most frequently in patients with chronic liver conditions (such as cirrhosis). Therefore, it is important to predict liver cancer more explicitly by using machine learning. This study examines the survival prediction of a dataset of HCC based on three strategies. Originally, missing values are estimated using mean, mode, and k-Nearest Neighbor (kNN). We then compare the different select features using the wrapper and embedded methods. The embedded method employs Least Absolute Shrinkage and Selection Operator (LASSO) and ridge regression in conjunction with Logistic Regression (LR). In the wrapper method, gradient boosting and random forests eliminate features recursively. Classification algorithms for predicting results include k-NN, Random Forest (RF), and Logistic Regression. The experimental results indicate that Recursive Feature Elimination with Gradient Boosting (RFE-GB) produces better results, with a 96.66% accuracy rate and a 95.66% F1-score.

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