Astrocytoma is the most common brain
tumor. The aberrant expression of programmed cell death
ligands 1 (PD-L) on tumor cells results in tumor immune
evasion with tumor aggressiveness in many cancers.
Materials and methods Immunohistochemical analysis
was used for examining the morphology and the expression
of PD-L1 and P53 in 42 cases of astrocytomas. Univariate
analysis was used to correlate the protein expression with
the variable clinicopathological parameters. Log-rank test
was used to compare the survival among the different
groups.
Results PD-L1 positive expression was found in 42.9%
(18/42) of patients with astrocytoma. PD-L1 positive
expression showed statistically significant association with
grade of astrocytoma (P=0.003), poor survival (P=0.005),
and recurrence (P=0.001). P53 high expression was found
in 47.6% (20/42) of patients with astrocytoma. P53 high
expression showed statistically significant association with
grade of astrocytoma (P=0.014), survival (P=0.032), and
recurrence (P=0.001). High significant association was
detected between PD-L1 positivity and P53 high expression
(P=0.005).
Conclusion The high expression of PD-L1 and P53 was
associated with higher grade and poor survival in
astrocytoma. A significant association between PD-L1 and
P53 might emphasize the interaction between P53 and
PD-L1 during astrocytoma progression. Egypt J Pathol
38:319–325 © 2018 Egyptian Journal of Pathology |
