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Dr. Reda ibrahim ahmed El kammar :: Publications: |
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| Title: | Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine. |
| Authors: | Asmaa Elsayed; Ashraf Elkomy; Mohamed Alkafafy; Reda Elkammar; Anwar El‑Shafey; Ahmed Soliman; Mohamed Aboubakr. |
| Year: | 2022 |
| Keywords: | Cisplatin · N-acetylcysteine · Lycopene · Oxidative stress · Testosterone · Testes |
| Journal: | Environmental Science and Pollution Research |
| Volume: | 29 |
| Issue: | Not Available |
| Pages: | 24077–24084 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | |
| Full paper | Reda ibrahim ahmed El kammar_3- Testicular toxicity of cisplatin in rats ameliorative effect of lycopene.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Lycopene (LP) and N-acetylcysteine (NAC) protective effects were assessed for testicular toxicity mediated by cisplatin (CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC + CP. Serum levels of testosterone were decreased following CP injection. Malondialdehyde (MDA) has been increased with considerable glutathione (GSH), and dismutase superoxide (SOD) and catalase (CAT) decline in the testis tissues after CP injection. CP caused severe alterations in testicular tissues and elevated caspase-3 expression. Besides that, LP and/or NAC administration improved CP-induced testicular toxicity and apoptosis, probably via their antioxidant properties. |
