Cisplatin (CP) is one of antineoplastic agents with a broad range of anticancer
activities. This research investigated the possible protective effects of lycopene
(LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven
groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg,
PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27th day of the
experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following
injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase
(LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in
serum of the treated groups. In addition, CP resulted in a significant increase in
malondialdehyde (MDA), as well as significant decreases in glutathione (GSH),
superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in
changes in cardiac histopathology and increased caspase-3 expression in cardiac
tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and
apoptosis induced by CP, through their antioxidant properties. |
