You are in:Home/Publications/Could α MSH-MIFT Axis and IDH2 be Considered Promising Predictors of Non-segmental Vitiligo Response to NB-UVB Phototherapy?

Dr. Rehab Mohammed Salem :: Publications:

Title:
Could α MSH-MIFT Axis and IDH2 be Considered Promising Predictors of Non-segmental Vitiligo Response to NB-UVB Phototherapy?
Authors: KHALED MOHEY ELDIN MONIB, MD; NEVEEN EMAD SOROUR, MD; NAGLAA FATHY ALHUSSEINI, MD; ASMAA GABER ABDOU, MD; AMAL YOUSIF, MD; and REHAB MOHAMMED SALEM
Year: 2023
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Rehab Mohammed Salem_Paper 5.pdf
Supplementary materials Not Available
Abstract:

The search for objective factors that help in predicting the response of vitiligo treatment is very important. OBJECTIVE: We sought to evaluate the e ect of NB-UVB phototherapy on both the alpha melanocyte stimulating hormone-microphthalmia-associated transcription factor (α-MSH-MIFT) axis, and isocitrate dehydrogenase 2 (IDH2) in non-segmental vitiligo (NSV). METHODS: This prospective clinical trial included 50 NSV patients and 50 healthy control subjects. α-MSH tissue levels as well as MITF and IDH2 immunostaining were assessed in normal and vitiliginous skin biopsies before treatment and then in the repigmented areas following 24 NB-UVB phototherapy treatment sessions using ELISA technique and immunohistochemical study, respectively. RESULTS: There was a signi cant negative correlation between baseline VASI scores and the tissue levels of α-MSH (p=0.006) and the expression of both MITF (p

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus