You are in:Home/Publications/Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo

Dr. Rehab Mohammed Salem :: Publications:

Title:
Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo
Authors: ABD ELAZIZ ELTAWEEL, MD; AMIRA ABDELRAHMAN, MD; HEBATALLAH HEGAZY, MSc; and REHAB SALEM, MD
Year: 2023
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Rehab Mohammed Salem_Paper 6.pdf
Supplementary materials Not Available
Abstract:

Granzyme B (GZMB) gene is related to human immunity and is considered as one of the genes indulged in vitiligo. OBJECTIVE: To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients. METHODS: This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals. The polymorphism of GZMB gene at (R55Q) and (P94A) were analyzed by polymerase chain reaction. RESULTS: P94Q and R55Q gene polymorphisms were signi cantly associated with higher VASI scores. CONCLUSION: GZMB (Q55R) and P94A) gene polymorphisms are associated with the susceptibility to develop vitiligo in the Egyptian population and could help predicting more extensive forms of the disease.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus