Diazinon (DZN) is a widely used organophosphrus synthetic and acaricide widely used for agricultural and veterinary purposes. However, its
human and animal exposure leads to hepatocardiotoxicity. Our experimental objective was to evaluate protective effects of Myrrh; Commiphora
molmol or/ and ascorbic acid; vitamin C against DZN-induced hepatocardiotoxicity in healthy male white New Zealand rabbits (Oryctolagus
cuniculus). DZN-treated animals revealed significant alterations in serum biochemical parameters related to hepatic and cardiac injuries. There
was a significant increase in hepatic and cardiac lipid peroxidation and significant inhibition in tissue antioxidant biomarkers due to DZN
intoxication. Both myrrh and vitamin C protect against DZN-induced serum as well as hepatic and cardiac tissue biochemical parameters when
used alone or in combination along with DZN-intoxication. Furthermore, both myrrh and vitamin C produced synergetic hepatocardioprotective
and antioxidant effects. Therefore, it could be concluded that myrrh and/or vitamin C administration able to minimize the toxic effects of DZN by
its free radical-scavenging and potent antioxidant activity.
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