Gum arabic has recently attracted attention because of its physiologic
activity and its role as antioxidant. This study was designed to compare the
AG with the established and well known drug, silymarin regarding to their
roles in protecting the liver in case of drug toxicity as by paracetamol,
through measuring their effect on liver enzymes SGOT, SGPT, and ALP
and on oxidative activity as evdenced by the level of MDA. This
research also measure the changes in portal preassure in different groups .
This work was done also to study AG effects on isolated perfused rabbit’s
jejunum in vitro.
As regards the in vivo study, rats were used and divided into four equal
groups each was 6 rats : control( group I ) , acetaminophen
adminsteredgroup (group II) (each rat received a single intra-peritoneal
injection of acetaminophen 500 mg / kg body weight ) , Arabic gum treated
group ( group III ) (each rat received 7.6 mg / kg dissolved in drinking
water for 5 days by oral route),and Silymarin treated group ( group IV )
(each rat received 200 mg / kg body orally for 5 days by oral route) and
Arabic gum and Silymarin treated group ( group V ) (each rat received
7.6 mg / kg dissolved in drinking water and 200 mg / kg body weigh orally
for 5 days).
At the end of the study, the rats were subjected to measuring liver enzymes
SGOT, SGPT, ALP and MDA levels in blood also the portal preassure was
measured and histopathological examination to liver cut sections was done.
Summary and Conclusion
١٠٢
It was found that AG and Silymarin produced a significant reduction in liver
enzymes SGOT, SGPT, ALP and MDA and in portal hypertention caused by
acetaminophen adminstration. Both AG and Silymarin produced significant
reduction of hydropic degeneration, hepatic necrosis, central vein congestion
and portal tract inflammation in liver sections.
AG was significantly more effective than Silymarin in reducing the liver
enzymes.
Adding AG to Silymarin was significantly more effective than Silymarin
alone in reducing the liver enzymes except ALP which was not significantly
affected
Adding AG to Silymarin was significantly effective than Silymarin alone in
reducing the oxidative activity
Pretreatment with AG and Silymarin before giving them a single intraperitoneal
injection of acetaminophen caused significant reduction in portal
pressure.
Adding AG to Silymarin was significantly more effective than Silymarin
alone in reducing the portal pressure.
In conclusion, oral administration of Arabic gum protected rats from
acetaminophen - induced hepatotoxicity. The protection is not through
change in metabolism of acetaminophen but may be through reduction of
Summary and Conclusion |
