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Dr. Safwa Mahmoud Soror :: Publications: |
|
| Title: | The Combination of Tamarindus indica
and Coenzyme Q10 can be a Potential
Therapy Preference to Attenuate
Cadmium-Induced Hepatorenal Injury |
| Authors: | Amany Abdelnaby1, Nabila Abdel-Aleem2, Ayman Mansour1, Afaf Abdelkader3,4*, Amany N. Ibrahim5, Safwa M. Sorour5, Enas Elgendy6, Heba Bayoumi6, Shaymaa M. Abdelrahman7, Samah F. Ibrahim8, Ilhaam Alsaati 9 and Ahmed Abdeen2,4,10 |
| Year: | 2023 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Safwa Mahmoud Soror_fphar-13-954030.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Cadmium (Cd) is a hazardous environmental pollutant that menaces human and animal health and induces serious adverse effects in various organs, particularly the liver and kidneys. Thus, the current study was designed to look into the possible mechanisms behind the ameliorative activities of Tamarindus indica (TM) and coenzyme Q10 (CoQ) combined therapy toward Cd-inflicted tissue injury. Male Wistar rats were categorized into seven groups: Control (received saline only); TM (50 mg/kg); CoQ (40mg/kg); Cd (2 mg/kg); (Cd + TM); (Cd + CoQ); and (Cd + TM+ CoQ). All the treatments were employed once daily via oral gavage for 28 consecutive days. The results revealed that Cd exposure considerably induced liver and kidney damage, evidenced by enhancement of liver and kidney function tests. In addition, Cd intoxication could provoke oxidative stress evidenced by markedly decreased glutathione (GSH) content and catalase (CAT) activity alongside a substantial increase in malondialdehyde (MDA) concentrations in the hepatic and renal |
