Background: Androgenetic alopecia (AGA) is a prevalent condition with a complex
etiopathogenesis. Angiotensin-converting
enzyme (ACE) gene located on the chromosome
17q23 contains an insertion (I) and deletion (D) polymorphism in the intron
16. This gene polymorphism plays a role in multiple inflammatory disorders. However,
there are no studies investigating its association with AGA susceptibility.
Objectives: In this work, we aimed at exploring the association of ACE gene I/D polymorphism
in AGA susceptibility in a group of Egyptian patients.
Methods: This study included 100 AGA patients, and 100 apparently healthy controls.
The ACE gene I/D polymorphism was analyzed by polymerase chain reaction.
Results: The DD, ID genotypes, and D allele showed higher frequent distribution
among studied AGA patients than controls (p < 0.05 each). Positive family history
and ACE gene I/D polymorphism were considered AGA susceptibility predictors in
both uni-and
multivariable analyses [p < 0.05 each (OR (95% CI)] on applying logistic
regression analysis for risk factors prediction.
Conclusions: This study highlights the possible contribution of the suspected genetic
polymorphism as a susceptibility indicator for AGA development in the examined
group of patients. |
