Background
Narrow-band ultraviolet B (NB-UVB) is a crucial and effective line of treatment for
nonsegmental vitiligo.
Objective
To compare the effect of adding platelet-rich plasma (PRP) injections versus
microneedling sessions on the response to NB-UVB in patients who stopped
giving response or did not give response from the start.
Patients and methods
An intrapatient randomized comparative study including 30 patients with stable,
nonsegmental vitiligo was performed. Three lesions were assessed in each
participant and randomly allocated to undergo PRP injections or microneedling
every 2 weeks for four sessions. The third lesion was left as a control. Throughout
the study, all lesions were subjected to NB-UVB three times a week. Photographic
assessment by an independent dermatologist and a patient satisfaction
questionnaire were used to assess repigmentation.
Results
PRP injection showed better results than microneedling in terms of repigmentation,
complications, and patient satisfaction. The mean percentages of repigmentation in
PRP, microneedling-treated, and control lesions were 58.17±21.52, 24.5±18.77,
and 15.17±13.49, respectively (P |
