Alopecia areata (AA) is a prevalent autoimmune skin disease that may be
associated with systemic disorders. The connection between cardiovascular
risks and AA is not widely investigated. Chemokine (C-C motif) ligand 20
(CCL20) has been found to be related to cardiovascular comorbidities.
Objective
To investigate the role of CCL20 in AA patients and its relation to cardiovascular
comorbidity.
Patients and methods
This study enrolled 80 AA patients and 40 age and sex-matched control subjects.
Serums CCL20, high sensitive C- reactive protein (Hs-CRP), lipid profile in addition
to carotid intima-media thickness (CIMT) were investigated in all subjects.
Results
AA patients expressed significantly higher serum CCL20 levels than healthy
controls (29.6±20.4 vs. 10.3±6.7, P |
