Hyperlipidemia is a known risk factor for the development of cardiovascular disease including
atherosclerosis. This study was designed to evaluate the effect of oral intake ofTaurine (TU) on lipid
profile, glucose, insulin, insulin resistance (HOMA) in serum and anti-oxidant enzyme activities catalase
(CAT), superoxide dismutase (SOD), reduced glutathione(GSH) and L-MDA, in liver of high fat diet
induced hyperlipidemia in male albino rats by feeding high fat diet.One hundredmale albino rats were
divided into four equal groups of 25 rats each Group Ι :( Control normal group): rats fed normal diet.
Group II: (hyperlipidemic group): rats fed high fat diet (HFD) and administered no drugs. Group III
(HFD +TU): rats fed HFD and administeredtaurine once daily (500 mg/kgb.wt./day, orally) for 8 weeks.
Group IV (control positive): rats received the control normal diet andadministered taurine once daily
(500mg/kg b.wt. Orally) for 8 weeks. Blood samples were collected after 3, 6 and8 weeks from the
onset of taurine administration for determination of serum glucose, insulin, insulin resistance, total
cholesterol(TC), triacylglycerol(TAG), phospholipids, Low density lipoprotein-cholesterol (LDL-c),
Very low density lipoprotein-cholesterol (VLDL-c) and High density lipoprotein-cholesterol (HDL-c)
levels in addition to antioxidant enzymes activities in liver (CAT),(SOD),(GSH) and MDA
concentration in liver tissue .the obtained results revealed that, rats fedHFD exhibited significant
elevation of serum TC, TAG, ( VLDL-C), MDA with marked decreased in serum phospholipids
concentrations compared to rats fed normal diet. Meanwhile, administration of taurine to HFD-fed rats
tended to prevent hyperglycemia, improve dyslipidemia and other changes relevant to high fat diet
mainly through improving activities of anti-oxidant enzyme and scavenging free radical and
enhancement cholesterol metabolism to convert it to bile salts, which consequently reduce lipid profile
in serum and insulin resistance. These results suggest that, taurine is effective in improving the obesity
and coronary heart disease. |
