Background and aim of the work: Antioxidants can reduce damage produced by low doses of radiation
on living cells. This study was designed to investigate the effects of fermented soy milk (FSM) and low dose of
gamma radiation on carcinogenic effect of N-methyl-N-nitrosourea (MNU). Materials and methods: Female rats
were divided into 8 groups: group (1): control, group (2): injected with MNU, group (3): whole body exposed to
low dose of gamma radiation (0.5 Gy), group (4): given FSM orally, group (5): given FSM and MNU, group (6):
received FSM and exposed to gamma radiation, group (7): given FSM, MNU and exposed to gamma radiation.
Results: Fermented soy milk exerted significant, ameliorative effect on glutathione peroxidase, superoxide
dismutase and catalase activities, lipid peroxidation and TNF-α level and lipid profiles in rats injected with MNU.
Combined treatment of FSM and low dose of gamma radiation markedly elevated GSH level, ameliorated MNU
effect on cell cycle phases Go/1, S, G2/M and induce apoptosis via activation of caspase-3. Conclusion: FSM
consumption with exposure to low doses of gamma radiation reduced carcinogenesis and oxidative stress effects
induced by MNU in the mammary tissues. |
