Resveratrol is a phytoalexin polyphenol exhibiting antioxidant and anti-inflammatory properties. The present study
was designed to evaluate the potential protective and therapeutic effects of resveratrol (RSV) on ethanol-induced
gastritis in rats. Thirty two male rats divided into four groups. Normal control group: received no drugs, gastritisinduced group: administered with a single oral dose of 1 ml/rat of absolute ethanol, gastritis + RSV protected:
received RSV orally (10 mg/kg b. wt/day) for 2 days prior ethanol administration and gastritis + RSV treated:
received RSV as in group III and the treatment was continued for 7 days later. Blood samples and gastric tissue
specimens were collected for determination of serum and gastric tissue parameters. The obtained results showed a
significant decrease in serum nitric oxide (NO), sialic acid (SA), and gastric tissue GSH, vitamin C concentrations
and GPX, SOD, GR and CAT activities in gastritis induced rats. However, myeloperoxidase (MPO) and cyclooxygenase
II (COX-2) activities, NF-KB p65, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1beta (IL-
1β), L- Malondialdehyde (L-MDA) and DNA-fragmentation were significantly increased. Administration of RSV was
able to mitigate gastritis induced by ethanol through increasing of NO, SA, GSH, vitamin C concentrations,
enzymatic antioxidants status in addition to decreasing NF-KB p65, Pro-inflammatory cytokines, L-MDA, DNAfragmentation, MPO and COX-2. Additionally, various pathological changes in gastric tissues were observed in
gastritis induced rats. Interestingly, the severity of these alterations was reduced in resveratrol protected and
resveratrol treated groups with variable degree. The results suggest that, RSV may be effective in the therapeutic of
gastritis by its radical scavenging and antiapoptotic activity, inhibited neutrophil accumulation, restoring
endogenous antioxidant mechanisms and attenuate the severity of histopathological alterations in the gastric
mucosa. |
